Faculty of Virology

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C. Jane Welsh, Ph.D.
Professor
Veterinary Integrative Biosciences
Veterinary Pathobiology

Education:
B.Sc. London University, UK. Microbiology 1976
Ph.D. London University, UK Biochemistry/Immunology 1981

Research description:
Neuroimmunology, autoimmunity, neurotropic viruses, multiple sclerosis, blood-brain barrier, cerebrovascular endothelial cells, effects of stress on autoimmune disease

Representative Publications:
Welsh, C.J.R., Tonks, P., Nash, A.A. and Blakemore, W.F. (1987) The effect of L3T4 T cell depletion on the pathogenesis of Theiler's murine encephalomyelitis virus infection in CBA mice.  J. gen. Virol., 68, 1659-1667.

Blakemore, W.F., Welsh, C.J.R., Tonks, P. and Nash, A.A. (1988) Observations on demyelinating lesions induced by
Theiler's virus in CBA mice.  Acta Neuropath., 76, 581-589.

Welsh, C.J.R., Tonks, P., Borrow, P. and Nash, A.A. (1990) Theiler's virus: an experimental model of virus-induced demyelination.  Autoimmunity, 6, 105-112.

Borrow, P., Tonks, P., Welsh, C.J.R. and Nash, A.A. (1992) The role of CD8+ T cells in the acute and chronic phases of Theiler's virus-induced disease in mice.  J. gen. Virol., 73, 1861-1865.

Sapatino, B., Welsh, C.J.R., Smith, C.A., Bebo, B. and Linthicum, D.S. (1993) Cloned mouse cerebrovascular endothelial cells that maintain their differentiation markers for Factor VIII, low density lipoprotein and angiotensin-converting enzyme.  In Vitro Cell. Dev. Biol. 29A, 923-928.

Welsh, C.J.R., Sapatino, B., Rosenbaum, B., Smith, R. and Linthicum, D.S. (1993) Correlation between susceptibility to demyelination and interferon gamma induction of major histocompatibility complex class II antigens on murine cerebrovascular endothelial cells. J. Neuroimmunol., 48, 91-98.

Borrow, P., Welsh, C.J.R. and Nash, A.A.  (1993) Study of the mechanisms by which CD4+ T cells contribute to protection in Theiler’s murine encephalomyelitis.  Immunol., 80, 502-506.

Yong, T., Bebo, B.F., Sapatino, B., Welsh, J., Orr, E.L. and Linthicum, D.S.  (1994) Histamine induced microvascular leakage in pial venules: difference between SJL/j and BALB/c inbred strains of mice.  Journal of Neurotrauma, 11,161-171.

Welsh, C.J.R., Sapatino, B.V., Petrescu, A. and Piedrahita, J. (1995) The blood-brain barrier in virus-induced demyelination.  Adv. Exp. Med. Biol., 383,105-116.

Welsh, C.J.R., Sapatino, B.V., Rosenbaum, B. and Smith, R.  (1995) Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute Infection.  J. Neuroimmunol., 62, 119-125.

Sapatino, B.V., Petrescu, A., Rosenbaum, B., Piedrahita, J., Smith, R. and Welsh C.J.R. (1995) Characteristics of cloned cerebrovascular endothelial cells following infection with  Theiler's virus. II. Persistent infection.  J. Neuroimmunol., 62, 127-135.

Merriam, E.A., Campbell, B.D., Flood, L.P., Welsh, C.J.R., McDaniel, H.R. and Busbee, D.L. (1996) Enhancement of immune function utilizing a complex carbohydrate phytochemical which stimulates cytokine production and destruction of Norman Sarcoma in rodents.  Advances in Anti-Aging Medicine 1, 181-203.

Walker, D.H., Popov, V.L., Crocquet-Valdes, P.A., Welsh, C.J.R., and Feng, H.  (1997) Cytokine-induced, nitric oxide-dependent intracellular antirickettsial activity of mouse endothelial cells. J.  Lab Invest. 76,129-138.

Borrow, P., Welsh, C.J.R., Dean, D., Tonks, P., Blakemore, W.F., and Nash, A.A. (1998) Investigation of the role of autoimmune responses to myelin in the pathogenesis of Theiler’s virus-induced demyelinating disease.  Immunology, 93,478-484.

Qian, Y., Tiffany-Castiglioni, E., Welsh, C.J.R. and Harris, E. D. (1998) Copper efflux from murine microvascular cells requires expression of the Menke’s Cu-ATPase J. Nutrition, 128, 1276-1282.

Campbell, T., Meagher, M.W., Sieve, A., Scott, B., Storts, R., Welsh, T.H. and Welsh, C.J.R.  (2001) The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection.  I.  Acute disease.  Brain, Behavior and Immunity, 15, 235-254.

Tennakoon, D., Smith, R., Stewart, M.D., Spencer, T.E., Nayak, M. and Welsh, C.J.R.  (2001) Ovine interferon-tau modulates the expression of MHC antigens on murine cerebrovascular endothelial cells and inhibits replication of Theiler’s virus.  J. Interferon and Cytokine Research, 21, 785-792.

Girvin, A.M., Gordon, K.B., Welsh, C.J.R., Clipstone, N.A. and Miller, S.D. (2002) Differential abilities of central nervous system-resident endothelial cells and astrocytes to serve as inducible APCs. Blood 99, 3692-3701.

Datta, S., Park, Y., Rangel, C., Reynolds, M.M., Caldwell, M.C., Nayak, M., Welsh, C.J.R., McDermott, S. (2003) Drosophila Perlecan transduces FGF and hedgehog signals to activate stem cell division.  Developmental  Biology, 253, 247-257.

Welsh, C.J.R., Bustamante, L., Nayak, M., Welsh, T.H., Dean, D.D. and Meagher, M.W. (2004) The effects of restraint stress on the neuropathogenesis of Theiler’s virus infection II: NK cell function and cytokine levels in acute disease. Brain, Behavior and Immunity, 18, 166-174.

Johnson, R.R., Storts, R., Welsh, T.H., Welsh, C.J.R. and Meagher, M.W. (2004) Social stress alters the severity of acute Theiler’s virus infection. J. Neuroimmunology. 148, 74-85.

Mi, W., Belyavskyi , M., Johnson, R.R., Sieve, A.N., Storts, R., Meagher, M.W. and Welsh, C.J.R.  (2004) Alterations in chemokine expression in Theiler’s virus infection and restraint stress.  J. Neuroimmunology, 151, 103-115.

Sieve, A. N., Steelman, A.J., Young C.R., Storts, R., Welsh, T.H., Welsh, C. J. R., and Meagher, M. W. (2004).  Chronic restraint stress during early Theiler’s virus infection exacerbates the subsequent demyelinating disease in SJL mice.  J. Neuroimmunol., 155, 103-118.

Johnson, R.R., Prentice T., Bridegam, P., Young C.R., Steelman A.J., Welsh, T.H., Welsh, C.J.R. and Meagher, M.W. (2006) Social stress alters the severity and onset of the chronic phase of Theiler’s virus infection. J. Neuroimmunology, 175, 39-51.

Villarreal, D., Young, C.R., Storts, R., Ting, J.W., and Welsh, C.J.R. (2006) A comparison of the neurotropism of Theiler’s virus and poliovirus in CBA mice.  Microbial Pathogenesis, 41 149-156.

Mi W., Young, C.R., Storts, R., Steelman, A., Meagher, M.W. and Welsh, C.J.R. (2006) Stress alters pathogenecity and facilitates systemic dissemination of Theiler’s virus.  Microbial Pathogenesis, 41, 133-143.

Mi, W., Prentice T.W., Young, C.R., Johnson, R.R., Sieve, A.N., Meagher, M.W., Welsh, C.J.R. (2006) Restraint stress decreases virus-induced pro-inflammatory cytokine expression during acute Theiler’s virus infection. J. Neuroimmunology, 178: 49-61.

Sieve, A. N., Steelman, A.J., Young C.R., Storts, R., Welsh, T.H., Welsh, C. J. R., and Meagher, M. W.  (2006) Sex dependent effects of chronic restraint stress during early Theiler’s virus infection on the subsequent demyelinating disease in CBA mice. J. Neuroimmunol. 177, 46-62.

Meagher, M.W., Johnson, R.R., Vichaya, E. G., Young, E.E., Lunt, S. and Welsh, C.J.R.  (2007) Social conflict exacerbates an animal model of multiple sclerosis. Trauma, Violence, and Abuse, 8, 314-330.

Fuller, A., Yahikozawa, H., So, E.Y., Dal  Canto, M., Koh, C.S., Welsh, C.J. and Kim, B.S. (2007) Castration of male C57L/J mice increases susceptibility and estrogen treatment restores resistance to Theiler’s virus-induced demyelinating disease. J Neurosci. Res.

Meagher, M.W., Johnson, R.R., Young, E.E., Vichaya, E.G., Lunt, S., Hardin, E.A., Connor, M.A., Welsh, C.J.R. (2007) Interleukin 6 as a mechanism for the adverse effects of social stress on acute Theiler’s virus infection.  Brain Behavior and Immunity 21, 1083-1095.

Young, E.E., Prentice, T.W., Satterlee, D., McCullough, H., Sieve, A.N., Johnson, R.R., Welsh, T.H., Welsh, C.J.R., and Meagher, M.W.  (2008)  Glucocorticoid exposure alters the pathogenesis of Theiler's murine encephalomyelitis virus during acute infection.  Physiology and Behavior.

Chapters In Books:
Welsh, C.J.R., Blakemore, W.F., Tonks, P., Borrow, P. and Nash, A.A. (1989).  Theiler's murine encephalomyelitis virus infection in mice: a persistent viral infection of the central nervous system which induces demyelination. In: Immune responses, Virus Infection and Disease (pp125-147).  Published by Oxford University Press.  Editor: Nigel Dimmock.

Meagher, M.W., Johnson, R.R., Good, E., and Welsh, C.J. (2006) Social stress alters the severity of an animal  model of multiple sclerosis.  In C. Jane Welsh, Mary W. Meagher and Esther Sternberg (eds.), Neural and neuroendocrine mechanisms in host defense and autoimmunity. New York: Springer, pp. 216-240.

Welsh, C.J., Mi, W., Sieve, A., Steelman, A.J., Johnson, R.R. Young, C.R., Prentice, T., Hammons, A. Storts, R. Welsh, T.  and Meagher, M.M.  (2006) The effect of restraint stress on the neuropathogenesis of Theiler’s virus-induced demyelination, a murine model for multiple sclerosis. In C. Jane Welsh, Mary W. Meagher and Esther Sternberg (eds.), Neural and neuroendocrine mechanisms in host defense and autoimmunity. New York: Springer, pp. 190-225.

Meagher, M.W., Johnson, R.R., Good, E., and Welsh, C.J. (2006) Social stress alters the severity of a virally initiated model of multiple sclerosis.  Editor in Chief Robert Ader Fourth Edition of Psychoneuroimmunology. Publisher Elsevier Inc. San Diego, CA.

Young, C.R. and Welsh, C.J.R. (2008) Animal models of multiple sclerosis. In P. Micheal Conn Editor Sourcebook of models for biomedical research.  Humana Press, New Jersey pp. 665-676.

Welsh, C.J.R. and Young, C.R. (2006) Autoimmune processes in the central nervous system.  Handbook of Neurochemistry and Molecular Neurobiology Volume 19, Neuroimmunology.

Welsh, C.J.R., Steelman, A.J. , Sieve, A.N. Mi, W., Johnson, R.R., Young, C.R., Prentice, T.W. and Meagher M.W. (2008) Neuroendocrine-immune interactions in neurotropic viral infections. Chapter in Neurotropic Viral Infections. Edited by Carol Shoshkes Reiss. Cambridge University Press, UK  

 

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