Faculty of Virology

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Linda A. Guarino
Professor of Biochemistry and Biophysics
Faculty of Genetics

Education:
B.A. University of Colorado at Boulder 1973
Ph.D. University of Colorado Medical Center 1979

Research Description: Molecular genetic and biochemical approach to examining viral-host interactions. Characterizing the function of viral factors which control the temporal regulation of polyhedrin expression to obtain maximum levels of expression in insect cells, and the mechanism of action and formation of the 39K Autographa californica nuclear polyhedrosis virus (AcNPV) is regulated by both a trans-acting viral factor and a cis-acting. Elucidate the function of viral ubiquitin and how that function is related to the amino acid sequence.

Representative Publications:

Gong, M. and L.A. Guarino. 1998. Mapping of ORF-121, a factor that activates baculovirus early gene expression. Virology 244:495-503.

Guarino, L.A., B. Xu, J. Jin, and W. Dong. 1998 A viral-encoded RNA polylmerase purified from baculovirus infected cells. J. Virol: 772:7985-7991.

Jin, J., W. Dong, and L. Guarino. 1998. The LEF-4 subunit of baculovirus RNA polymerase has b'-RNA triphosphatase and ARPase activities. J. Virol. 72: 10011-10019.

Guarino L. A. , J. Jin, and W. Dong. 1998 Guanylyltransferase activity of the LEF-4 subunit of baculovirus RNA polymerase. J. Virol 72: 10003-10010.

 

 

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