Faculty of Virology

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Susan L. Payne
Associate Professor
Department of Veterinary Pathobiology

Education
B.S. - University of Massachusetts at Dartmouth, 1978
Ph.D. - Louisiana State University 1983 (Microbiology)

Research Description
My program is research involves studies of equine infectious anemia virus (EIAV), a retrovirus related to the human immunodeficiency virus (HIV). In order to solve the challenges of lentivirus control and/or eradication it is imperative to gain a better understanding of all aspects of their replication and virus/host interactions. The overall long term goal of my research program is to understand key aspects of the virus life-cycle (gene expression, gene regulation and mutation) of EIAV as they relate to pathogenesis. A related research focus is the study of host-virus interactions such as the dynamics of the immune response, the development of virus populations within a host, and modulation of immune responses by the virus.

Representative Publications
Fagerness, A.J., Flaherty, M.T., Perry, S.T., Jia, B., Payne, S.L., Fuller, F.J. 2006. The S2 accessory gene of equine infectious anemia virus is essential for expression of disease in ponies. Virology. In Press.

Ball, J.M., Swaggerty, C.L., Pei, X-F., Lim, W-S., Xu, X., Cox, V.C., Payne, S.L. SU proteins from virulent and avirulent EIAV demonstrate distinct biological properties. Virology. 333:132-144. 2005.

Lim, W.-S., Payne, S. L., Edwards, J. F., Kim, I. and J. M. Ball. Differential Effects of Virulent and Avirulent Equine Infectious Anemia Virus on Macrophage Cytokine Expression. Virology. 332:295-306. 2005.

Payne, S.L., Pei, X.F., Jia, B., Fagerness, A., Fuller, F. (2004). Influence of long terminal repeat and env on the virulence phenotype of equine infectious anemia virus. J. Virol. 78:2478-2485.

Lim, W.-S., Edwards, J.F., Boyd, N.K. Payne, S.L., and Ball J.M. Simultaneous quantitation of equine cytokine mRNAs using a multi-probe ribonuclease protection assay. Veterinary Immunology and Immunopathology. 91:45-51. 2003.

Payne, S.L., and Elder, J.H. The role of retrovirol dUTPases in replication and virulence. Curr Protein and Peptide Sci. 2:381-388, 2001.

Payne, S.L., La Celle, K., Pei, X., Qi, X., Shao, H., Steagall, W., Perry, S., and Fuller, F. Long terminal repeat sequences of equine infectious anaemia virus are a major determinant of cell tropism. J. Gen Virol. 80:755-759, 1999.

Payne, S.L., Qi, X.M., Dwyer, A., and Fuller, F. Disease induction by virus derived from molecular clones of equine infectious anemia virus. J. Virol. 72: 483-487, 1998.

Shao, H., Robek, M. D., Threadgill, D. T., Mankowski, L. S., Cameron, C. E., Fuller, F. J., and Payne, S. L. Characterisation and mutational studies of equine infectious anemia virus dUTPase. Biochimica et Biophysica Acta. 1339:181-191. 1997.

Steagall, W.K., Robek, M.D., Perry, S.T., Fuller, F.J. and Payne, S. L. Incorporation of uracil into viral DNA correlates with reduced replication of equine infectious anemia virus in macrophages. Virology. 210:302-313. 1995.

 

 

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