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VTMI 647

Viral Pathogenesis

Credit Hours: 4

SPRING 2000

Instructors: Dr. Judith Ball

Grading:

Class Discussion 50% (250 pts. 10-12 pts./class discussion)

Take-home exam 20% (100 pts.)

Proposal 30% (150 pts.)

**You will be given and are responsible for 2-4 papers/session. You are expected to know the replication scheme, taxonomy, and basic structure of the virus being discussed in each paper. You will be expected to understand and be able to explain pertinent background information as it relates to the manuscript. Yes, you will likely need to refer to a basic virology text or review paper to acquire this information. Finally, you are expected to critique the methods, the results and the conclusions drawn.

There will be no written exams. NO memorization / regurgitation.

Topics Covered:
Tropism 1 - viral dissemination
Tropism 2 - portal of entry
Tropism 3 - local replication
Tropism 4 -Cell Polarity and its affect on tropism
Immunopathogenesis 1 - immune evasion
Immunopathogenesis 2 - mimicry and autoimmunity
Immunopathogenesis 3 - immune enhancement
Immunopathogenesis 4 - immune pathology
Persistence and latency 1 - antigenic variation; quasispecies
Persistence and latency 2 - retroviruses
Persistence and latency 3 - herpes viruses
Persistence and latency 4 - CTL escape mutants
Virus-Cell Interactions 1 - viral membrane and cell fusion
Virus-Cell Interactions 2 - cellular receptors
Virus-Cell Interactions 3 - role of cell cycle and viral transcription
Nonspecific Host Responses 1 - viral modulators (CRM)
Nonspecific Host Responses 2 - jak/stat signal tranduction pathway
Nonspecific Host Responses 3 - other signal transduction pathways
Nonspecific Host Responses 4 - viral proteins that form ion channels
Nonspecific Host Responses 5 - viral mechanisms of apoptosis
Oncogenesis 1 - p53, cell cycle
Oncogenesis 2 - oncogenes
Oncogenesis 3 - DNA virus tumors
Viral vaccines 1 -traditional (poxvirus, measles) vaccines
Viral vaccines 2 - subunit and DNA vaccines

 

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